ALERT

iLab Operations Software Support will be staffed at reduced levels during the week Feb. 25 - Mar 1. iLab Support will prioritize critical issues (i.e. issues that prevent key workflows from completing). Regular support tickets will be monitored periodically. To escalate an issue, please add "Urgent" to the ticket / email subject or if dialling the iLab support phone press "1" when prompted (regional specific numbers can be found here). You can also refer to the iLab Help Site and iLab Status Page for site information.

X-ray Crystallography & Molecular Characterization Shared Resource

Overview of Services

This facility serves the needs of SKCC research programs in crystallization, X-ray data collection, structure determination, refinement and structural analysis of macromolecules. The facility has HydraIIPlusOne and Oryx8 crystallization robots for high-throughput crystallization screening and maintains Rigaku MicroMax-007HF microfocus rotating anode X-ray generator dual equipped for data collection from macromolecular crystals and Small Angle X-Ray Scattering (SAXS). The left port of this instrument, dedicated to X-ray data collection from macromolecular crystals, is equipped with high focusing mirrors and a new ultrafast PILATUS 200K Hybrid Pixel Array Detector and a X-stream 2000 cryogenic system, while the right port hosts a new BioSAXS-2000 2D Kratky SAXS system.

The facility also provides access to instrumentation for biophysical characterization of proteins, and protein/protein and protein/DNA interactions. These instruments include a Beckman Coulter Analytical Ultracentrifuge (ProteomeLab XL-I/A Protein Characterization System), a JASCO J-810 Spectropolarimeter, a BIACORE 3000 SPR biosensor, a KinExA 3000, and two Isothermal Titration Calorimeters: MicroCal-ITC and a TA Instruments Nano-ITC.

Leadership

Gino Cingolani, Ph.D | Director, X-ray Crystallography

Michael J. Root, MD, Ph.D | Director, Molecular Characterization

Anshul Bhardwaj, Ph.D | Facility Manager, X-ray Crystallography and Molecular Characterization Shared Resource

Location and hours of operation

Hours Location

Staffed Monday - Friday, 9am - 5:00pm          

24/7 access for trained users

BLSB #822
233 S. 10th Street
Philadelphia, PA 19107

Links and Resources

Contacts

Name Role Phone Email Location
Anshul Bhardwaj, PhD
Manager
 
(215) 503-4587
 
anshul.bhardwaj@jefferson.edu
 
822 BLSB
 
Gino Cingolani, Ph.D.
Director
 
(215) 503-4573
 
gino.cingolani@jefferson.edu
 
826 BLSB
 

Map


https://goo.gl/maps/QdEEHgUXwXE2