X-ray Crystallography & Molecular Characterization Shared Resource

Overview of Services

This facility serves the needs of SKCC research programs in crystallization, X-ray data collection, structure determination, refinement and structural analysis of macromolecules. The facility has HydraIIPlusOne and Oryx8 crystallization robots for high-throughput crystallization screening and maintains Rigaku MicroMax-007HF microfocus rotating anode X-ray generator dual equipped for data collection from macromolecular crystals and Small Angle X-Ray Scattering (SAXS). The left port of this instrument, dedicated to X-ray data collection from macromolecular crystals, is equipped with high focusing mirrors and a new ultrafast PILATUS 200K Hybrid Pixel Array Detector and a X-stream 2000 cryogenic system, while the right port hosts a new BioSAXS-2000 2D Kratky SAXS system.

The facility also provides access to instrumentation for biophysical characterization of proteins, and protein/protein and protein/DNA interactions. These instruments include a Beckman Coulter Analytical Ultracentrifuge (ProteomeLab XL-I/A Protein Characterization System), a JASCO J-810 Spectropolarimeter, a BIACORE 3000 SPR biosensor, a KinExA 3000, and two Isothermal Titration Calorimeters: MicroCal-ITC and a TA Instruments Nano-ITC.

Leadership

Gino Cingolani, Ph.D | Director, X-ray Crystallography

Michael J. Root, MD, Ph.D | Director, Molecular Characterization

Anshul Bhardwaj, Ph.D | Facility Manager, X-ray Crystallography and Molecular Characterization Shared Resource

Location and hours of operation

Hours Location

Staffed Monday - Friday, 9am - 5:00pm          

24/7 access for trained users

BLSB #822
233 S. 10th Street
Philadelphia, PA 19107

Links and Resources

Contacts

Name Role Phone Email Location
Anshul Bhardwaj, PhD
Manager
 
(215) 503-4587
 
anshul.bhardwaj@jefferson.edu
 
822 BLSB
 
Gino Cingolani, Ph.D.
Director
 
(215) 503-4573
 
gino.cingolani@jefferson.edu
 
826 BLSB
 

Map


https://goo.gl/maps/QdEEHgUXwXE2


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